On Thursday, November 6, 2025, a serious traffic incident unfolded on Interstate 465 on Indianapolis's south side, resulting in significant disruptions to afternoon commute traffic. The crash occurred at approximately 1:20 p.m.

A tragic pedestrian fatality occurred on Interstate 465 on Indianapolis's northwest side during the early morning hours of Sunday, August 3, 2025. According to the Indiana Department of Transportation (INDOT), the fatal collision took place around 3:30 a.m.

A fatal motorcycle crash shut down Interstate 465 on Indianapolis' north side for over two hours early Sunday morning, June 29, 2025. The tragic incident occurred just after 1:00 a.m.